Epicardial cell transformation
نویسندگان
چکیده
منابع مشابه
Epicardial tumour originating from renal cell carcinoma.
A 66-year old male was admitted for indications of a cardiac tumour. Chest magnetic resonance imaging (MRI) showed a hyper-vascular tumour on the pericardium (Fig. 1A–C). A cardiac three-dimensional (3D) computed tomography (CT) shows that the tumour was located exactly on a coronary artery (Fig. 2). An open biopsy proved that the metastasis originated in renal cell carcinoma. Figure 1: Chest M...
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The myocardium of the developing heart tube is covered by epicardium. These epicardial cells undergo a process of epithelial-to-mesenchymal transformation (EMT) and develop into epicardium-derived cells (EPDCs). The ingrowing EPDCs differentiate into several celltypes of which the cardiac fibroblasts form the main group. Disturbance of EMT of the epicardium leads to serious hypoplasia of the my...
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BACKGROUND The epicardium has key functions during myocardial development, by contributing to the formation of coronary endothelial and smooth muscle cells, cardiac fibroblasts, and potentially cardiomyocytes. The epicardium plays a morphogenetic role by emitting signals to promote and maintain cardiomyocyte proliferation. In a regenerative context, the adult epicardium might comprise a progeni...
متن کاملEpicardial Lineages
The epicardium is the mono-layered epithelium that covers the outer surface of the myocardium from early in cardiac development. Long thought to act merely passively to protect the myocardium from frictional forces in the pericardial cavity during the enduring contraction and expansion cycles of the heart, it is now considered to be a crucial source of cells and signals that direct myocardial g...
متن کاملHuman Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
Human pluripotent stem cells (hPSCs) are widely used to study cardiovascular cell differentiation and function. Here, we induced differentiation of hPSCs (both embryonic and induced) to proepicardial/epicardial progenitor cells that cover the heart during development. Addition of retinoic acid (RA) and bone morphogenetic protein 4 (BMP4) promoted expression of the mesodermal marker PDGFRα, upre...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.62.1